| abstract |
The present invention relates to the field of medicinal chemistry and relates to a class of macrocyclic heterocyclic compounds as EGFR inhibitors, and the use thereof; specifically provided in the present invention are compounds as represented by formula (I) or an isomer, a pharmaceutically acceptable salt, a solvate, a crystal, or a prodrug thereof, a preparation method therefor, a pharmaceutical composition containing said compounds, and the use of said compounds or composition in the treatment of EGFR-mediated diseases. |