| abstract |
An injectable scaffold comprising a plurality of unclad microfibers and a diluent solution; and a method of repairing a soft tissue defect, in a subject, wherein the method comprises obtaining a microfiber stretch-and-fold ring comprising a plurality of microfibers and a cladding, shaving the stretch-and-fold ring into a plurality of chips, dissolving the cladding from the chips by contacting the chips with the uncladding solution to unclad the microfibers, hydrating the uncladded microfibers with a hydrating solution, thereby forming a paste, introducing a plurality of cells into the paste, thereby forming a seeded paste, loading the seeded paste into a syringe, and injecting the seeded paste into a region of interest. |