http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022125536-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_609a3b3ea85d9486baa78cdd8ff5482a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-254 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-252 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-365 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-36 |
| filingDate | 2021-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7239a841fc9ccc3be3923fee1924f7b9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_662fb78bdd1b0beafcfec0ced74cd67e |
| publicationDate | 2022-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2022125536-A1 |
| titleOfInvention | Fibrin-based bone substitute compositions and methods |
| abstract | Disclosed herein are fibrin-based bone substitute compositions, and methods of making and using them. An exemplary composition comprises thrombin; plasma comprising fibrinogen; an antibody comprising immunoglobulin G (IgG); and a plurality of granules comprising a bone substitute composition. The thrombin and the plasma comprise a fibrin gel, and the fibrin gel incorporates the antibody and the plurality of granules. A method of treating a bone defect comprises administering, to the bone defect, such a composition. A method of making a bone graft substitute comprises combining: an aqueous formulation of an antibody comprising immunoglobulin G (IgG); plasma containing fibrinogen; and a plurality of granules comprising a bone substitute composition; thereby forming an admixture of the antibody, the plasma, and the plurality of granules. The method further comprises contacting the admixture with thrombin, thereby forming a fibrin gel that incorporates the antibody and the plurality of granules. |
| priorityDate | 2020-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 422.