http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022117122-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b8d95a8e3200ca8bdb487861d99d2dba http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0d05849b5920b451e4c89fe803bdf0d1 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-138 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-245 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-138 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-245 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6883 |
| filingDate | 2022-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_779704c7bdf648a87aa7aabdd31ba9ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd2c58557dca7e0ff359d805eb3e52ee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b8405e5d3f48900bac44ee7867c132a |
| publicationDate | 2022-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2022117122-A1 |
| titleOfInvention | Use of ferroptosis inhibitor in preparing preparation for improving motor function of senescent individual |
| abstract | Provided is a use of a ferroptosis inhibitor in preparing a preparation for improving the motor function of a senescent individual. Transcriptome sequencing analysis has shown that TfR1 expression in skeletal muscle and muscle satellite cells decreases with increasing age. Muscle satellite cell-specific knockout of TfR1 results in irreversible inactivation of muscle satellite cells. The skeletal muscle regeneration process in TfR1 muscle satellite cell-specific mice is accompanied by muscle atrophy, iron ion accumulation and increased unsaturated fatty acid biosynthesis, thereby inducing skeletal muscle ferroptosis. Senescent skeletal muscle exhibits a decrease in TFR1 expression, while membrane surface accumulation of Slc39a14 promotes increased absorption of iron via binding with non-iron transport proteins, promoting the occurrence of ferroptosis. Intraperitoneal injection of ferrostatin-1 in senescent mice can significantly ameliorate muscle regeneration difficulties and motor difficulties caused by skeletal muscle death. |
| priorityDate | 2021-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 277.