Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_adc944faadcf9fe231f27e9b370a4bef |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-16632 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-16643 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-16621 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-763 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-869 |
filingDate |
2021-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa7aae4d0ee8f81f493fc2296c557b32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9db649aae3748c1c9dd62fe15cb4b3e8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88bdea6ec76a20180b0e081d88144db8 |
publicationDate |
2022-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-2022117073-A1 |
titleOfInvention |
Oncolytic herpes simplex type 1 viruses for treatment of brain tumors |
abstract |
Disclosed herein is an oncolytic HSV-1 virus genetically engineered for treatment of brain tumors, which lacks both copies of gamma 34.5 gene and an internal inverted repeat region and is optionally incorporated with immunostimulatory and/or immunotherapeutic genes. The oncolytic HSV-1 virus exhibited superior anti-tumor activity specifically in brain tumors. A pharmaceutical composition comprising the oncolytic HSV-1 virus and a pharmaceutically acceptable carrier, and a method of treatment of a brain tumor using the same is also disclosed. |
priorityDate |
2020-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |