| abstract |
Provided are the preparation and use of an anti-FSHR antibody and an antibody-drug conjugate thereof. Specifically, provided is an antibody or an antigen-binding fragment thereof, wherein the antibody or the antigen-binding fragment thereof comprises a variable region, which specifically binds to a human follicle-stimulating hormone receptor FSHR, and comprises one, two, three, four, five or six CDRs selected from the following amino acid sequences: SEQ ID NO: 6, 7, 5, 10, 11, and 12. The provided anti-FSHR antibody and the antibody-drug conjugate thereof have broad application prospects in the detection, screening, prevention and treatment of cancers. |