| abstract |
Provided herein are radiopharmaceutical conjugate compositions and uses thereof. In one aspect, provided herein are conjugates that comprise a GCC binding peptide, a metal chelator configured to bind with a radionuclide, a linker that attaches the GCC binding peptide with the metal chelator, and optionally a radionuclide. Also provided herein are conjugates that have improved elimination profile and plasma stability that are suitable for radiopharmaceutical applications and methods of using the same in treating and/or diagnosing diseases such as cancer. |