| abstract |
The disclosure provides a solid preparation having excellent dissolution of ibuprofen and a good color tone. The solid preparation includes a granular product containing the following ingredients (a1), (a2), (a3), and (a4):n(a1) ibuprofen or a salt thereof or a solvate thereof;n(a2) magnesium oxide;n(a3) sodium lauryl sulfate; andn(a4) one or more disintegrating agents selected from the group consisting of low substituted hydroxypropylcellulose, sodium carboxymethyl starch, carmellose, carmellose calcium, crospovidone, and croscarmellose sodium.nThe disclosure also provides methods of making such a solid preparation. |