| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_18d92c46f60af8af24e262b67381d7eb |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-43572
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-435
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 |
| filingDate |
2021-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b9ba14f0548d8cd222c444bdf98f30b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb7b924d12591b123a9fb2c9751ed134
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b8f2adc01befc66d80cd4a1d332eab4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a9ad90e42ba3cbdb142ada8f0463406
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad3be2c59ae5924eb250920684d32064 |
| publicationDate |
2022-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2022109167-A1 |
| titleOfInvention |
Membrane-active peptides and methods for reversible blood- brain barrier opening |
| abstract |
The present disclosure is directed to a composition or combination comprising at least one membrane- active peptide, such as melittin, and at least one therapeutic and/or diagnostic agent. Methods of using the membrane- active peptides of the disclosure to open a blood-brain barrier and to deliver a therapeutic and/or a diagnostic agent to a central nervous system (CNS) of a subject in need thereof are also provided. When administered as an intra-arterial injection into the cerebrovasculature, membrane-active peptides, such as melittin, support reversible blood-brain barrier opening without neurological damage. |
| priorityDate |
2020-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |