| abstract |
The present invention provides a novel class of imidazothiazole compounds as ATX (Autotaxin) inhibitors, a pharmaceutical composition comprising the compound, and a use of the compound and the composition to treat a mammal suffering from a disease having a pathological characteristic of increased ATX expression, wherein the compound has the structure represented by formula (I), or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, tautomer, nitrogen oxide, metabolite, prodrug, or mixture thereof, wherein R 1a , R 1c , R 2 , R 3 , R 6 , Cy, Y, Z, and t all have the definitions described in the present invention. |