| abstract |
An application of a quinazoline derivative in preparation of drugs for preventing or treating gastrointestinal diseases. The structural formula of the quinazoline derivative is shown in formula (I). Experimental results show that the quinazoline derivative has a significant therapeutic effect on peptic ulcer disease and inflammatory bowel disease, has the activity 20-80 times higher than existing clinical drugs, and can effectively improve mucosal integrity, promote tissue morphology improvement, and recover body weight of animals; moreover, in this field, the quinazoline derivative is mainly used for treating cardiovascular and cerebrovascular diseases, relating to new uses for old drugs; the quinazoline derivative has a good clinical application prospect in clinic. |