| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3970ff2929243c84b2f197df598b9c59 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-517
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 |
| filingDate |
2020-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91caa8e15aac433aec4bc921a2173eab
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7465c9af6b0f4bdc9851d62fbe84f486
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8439df4d1abfe83c178f5a420737e980 |
| publicationDate |
2022-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2022099574-A1 |
| titleOfInvention |
Application of prazosin in preparation of drugs for treating and/or preventing cerebrovascular diseases |
| abstract |
An application of prazosin in preparation of drugs for treating and/or preventing cerebrovascular diseases, especially an application in preparation of drugs for treating cerebral ischemic stroke. The main mechanisms against ischemia evaluates the therapeutic effect of prazosin on cerebral ischemic stroke by using an MCAO cerebral ischemia-reperfusion injury animal model. The experiment result shows that prazosin has the effect of treating cerebral ischemic stroke, and can improve cerebral infarction to a greater extent compared with butylphthalide for clinical use. Prazosin realizes the effect against cerebral ischemia-reperfusion injury mainly by reducing the extent of oxidative stress damage, improving inflammatory reaction and inhibiting cell death, etc. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115317484-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115317484-B |
| priorityDate |
2020-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |