| abstract |
The present invention relates to a composition for enhancing tumor penetration of an anticancer drug, comprising losartan as an active ingredient, and a use thereof. In the composition, losartan decomposes collagen and hyaluronic acid, which are main components of the extracellular matrix, to enhance the penetration of various anticancer drugs, including an antibody for cancer treatment, into the center of a tumor and uniformly distribute the various anticancer drugs, thereby improving a cancer treatment effect of an anticancer drug. Therefore, according to the present invention, by using combination therapy of losartan and an anticancer drug including an antibody for cancer treatment, penetration of the anticancer drug into the center of tumor can be enhanced, thereby making it possible to treat cancer more effectively. |