| abstract |
Disclosed are the preparation of a specific heat shock protein 90α subtype inhibitor and the use thereof. The inhibitor has the structure of formula I, wherein: R1 is selected from chlorine, fluorine, bromine, a C1-C3 alkyl, or a 1 to 6 fluorine substituted C1-C3; R2 is selected from chlorine, fluorine, bromine, a C1-C3 alkyl, a 1 to 6 fluorine substituted C1-C3 alkyl, -(C1-C6 alkenyl)-OH, -(C1-C6 alkyl)-OH, -O-(C1-C6 alkyl), -O-(C1-C6 alkenyl), -(C1-C6 alkenyl)-O-(C1-C6 alkyl), -(C1-C6 alkenyl)-O-(C1-C6 alkenyl)-(C6-C10 aryl), -(C1-C6 alkenyl)-O-(C1-C6 alkenyl)-(C3-C10 cycloalkyl), -(C1-C6 alkenyl)-O-(C1-C6 alkenyl)-(C3-C10 heterocycle), -(C1-C6 alkenyl)-O-(C2-C6 alkenyl), -O-(C1-C6 alkenyl)-(C3-C10 heterocycle), -O-(C2-C6 alkyl)-(C3-C10 heterocycle) or a C1-C8 alkoxy; R3 is selected from oxygen, imino, sulfur, or methylene; R4 is selected from a hydrogen group, a C1-C6 alkyl, a C2-C8 alkenyl or alkynyl, a C6-C14 aryl, a C2-C9 heteroaryl or isocycloalkyl, or a C3-C8 cycloalkyl; X: a nitrogen or carbon atom; Y is a nitrogen, sulfur, oxygen, or carbon atom; and n is selected from 0-5. |