| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_43a72884e25aaecffebe0942132d704f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ed3c2f63a5b1c705b1b389a6f1f1f7c8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c7d4d0cdc9f5df2ad6a9e21f7ad7611
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7c8846983bb28e088b9cec0b9a1eb6c6 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5073
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4703 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57407
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate |
2021-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a80c7e363b7c30be065b068ad979561c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0422c699231cedfc26352025ae55a859 |
| publicationDate |
2022-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2022084531-A1 |
| titleOfInvention |
Methods and compositions for treating glioma |
| abstract |
The present invention relates to a method for treating glioma in a subject in need thereof comprising a step of administering the subject with a therapeutically effective amount of Junction-mediating and regulatory protein (JMY) inhibitor. Inventors have demonstrated that sublethal doses of irradiation promote the migration and invasiveness of human GSC lines using in vitro and in vivo assays. They have shown that radiation-induced migration occurs through the stabilization and nuclear accumulation of the transcription factor hypoxia-inducible factor 1 alpha (HIT la), which drives the transcription of Junction-mediating and regulatory protein (JMY). Interestingly, sub-lethal irradiation did not trigger the HIF1 a/JMY pathway or consistently enhance motility in differentiated glioma cells, suggesting that the pathway is specifically linked to cancer cells with stem-like properties. These data could thus open the way to the development of new therapeutic strategies targeting JMY to improve the efficacy of radiotherapy and prevent glioma recurrence associated with GSC migration. |
| priorityDate |
2020-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |