| abstract |
The invention relates to compounds according to Formula (I) wherein A is –As(OH) 2 or an arsenoxide equivalent group; each of R 1 , R 2 , R 3 and R 4 is independently selected from H, X, OH, NH 2 , CO, SCN, -CH 2 NH, -NHCOCH 3 , -NHCOCH 2 X or NO, and X is a halogen; R 5 is –NHCH 2 COOH, OH or OR 6 , wherein R6 is a C 1-5 straight or branched alkyl group; and Z is a therapeutic radioisotope, or a pharmaceutically acceptable salt, ester, prodrug or solvate thereof, uses of said compounds, and methods of preparing said compounds. The invention also relates to therapeutic methods utilizing said compounds. The invention further relates to processes for preparing compounds according to Formula (I) wherein Z is a radioisotope. |