http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022065859-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0272d70c9ba3abebfdf08dc6b96f1120 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate | 2021-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f1fb132396d8eb87e5482b43ac59c90 |
| publicationDate | 2022-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2022065859-A1 |
| titleOfInvention | Method for direct reprogramming from somatic cells into pancreatic beta cells by using microrna, and differentiation composition |
| abstract | The present invention relates to a method for direct reprogramming from somatic cells into pancreatic beta cells by using microRNA and a small-molecule material. The inventors of the present invention confirmed that, as a result of having attempted direct reprogramming upon combined treatment of microRNA and small-molecule materials such as various differentiation-inducing materials, the expression level of PDX1 remarkably increased in pancreatic beta cells, and, when pancreatic beta-like cells were induced using such a method, direct reprogramming was performed with very high yield. In addition, since autologous cells are used, the present invention has the advantages of no occurrence of immune rejection responses and a low possibility of developing cancer, and thus is expected to be effectively used in the development of safer cellular therapeutic agents. In addition, pancreatic beta cells produced by the present invention are expected to be effectively used in a cellular composition for preventing, treating and ameliorating diabetes or pancreatic cancer. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114196614-A |
| priorityDate | 2020-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 187.