| abstract |
A medicine for treating or preventing diseases related to the activity of an LRRK2 kinase or an abnormal LRRK2 mutant kinase, which belongs to the field of medicine. The medicine comprises at least one of a compound represented by chemical formula 1, an optical isomer, a prodrug, a salt, a hydrate, a solvate, an N-oxide and a deuterated analog thereof, has a very good inhibition effect on the LRRK2 kinase or abnormal LRRK2 mutant kinase, and can be used for treating or preventing diseases related to the activity of the LRRK2 kinase or abnormal LRRK2 mutant kinase, such as Alzheimer's disease, L-dopa-induced dyskinesia, Parkinson's disease, dementia, kidney cancer, breast cancer, prostate cancer, leukemia, papilloma, lung cancer, acute myeloid leukemia, multiple myeloma, leprosy, Crohn's disease, inflammatory bowel disease, ulcerative colitis, amyotrophic lateral sclerosis, rheumatoid arthritis or ankylosing spondylitis. |