| abstract |
A bispecific recombinant protein, comprising a first functional binding fragment, a second functional binding fragment, and an Fc region. The first functional binding fragment targeting an antigen of interest of the bispecific recombinant protein comprises an antigen-binding fragment, wherein the C-terminus of the CL domain or the C-terminus of the CH1 domain in the antigen-binding fragment is directly connected to or is connected via a linker sequence to the second functional binding fragment having the functions of immunoregulation and/or metabolic regulation and/or endocrine regulation. Further disclosed is the use of the bispecific recombinant protein in the preparation of a drug for treating tumors, autoimmune diseases, infectious diseases, sepsis, graft-versus-host diseases, metabolic disorders and endocrine disorders. The recombinant protein can improve the targeting for the target of the second functional binding fragment of the bispecific recombinant protein and can also reduce toxic side effects caused by the non-target protein containing the second functional binding fragment generated during the preparation process targeting non-target organs, tissues and cells. |