| abstract |
Disclosed in the present invention are a compound of formula Ia or IIa, a cis-trans isomer, enantiomer, diastereomer, racemate, tautomer, solvate, hydrate, or pharmaceutically acceptable salt thereof or a mixture of said substances, a pharmaceutical composition containing the compound, and a use of the compound as a GPR40 agonist, wherein n, E, E1, G1, L, R1, R2, R3, R4, R5, R5b, R6, R7, Ra, Rb, Rc, Rd, Re, Rf, Rg, Ri, Rj, X1, X2, X3, X4, Y, Y1, Z1, and possible isotope substitution markers for each element in the compound are as defined in the specification. |