http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022043410-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ca21c29aaa0f8648acd7434e56b839c0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_96c84c8efcc6aeaf350488384f4952ff http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_43a72884e25aaecffebe0942132d704f |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-02 |
| filingDate | 2021-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b657afc6809719f8057ded4fb39f6ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_236e6aa6d80be18b59e9d6ae35d6b5b6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_237734a95056b44c758797faf7a768ec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0bc165f1df42e2d66e2107bf1068d45e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc852dc72c07db2abab8dd06d5d3d2f2 |
| publicationDate | 2022-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2022043410-A1 |
| titleOfInvention | Methods of treating nerve injuries |
| abstract | Peripheral nerve injury (PNI) is frequent and many patients suffer lifelong disabilities in severe cases. Now, the inventors tested in a facial nerve regeneration model the therapeutic effect of a short mimetic peptide, named PSELT, which derives from SELENOT, an essential thioredoxinlike selenoprotein endowed with neuroprotective and antioxidant activities. The effects observed were compared to those found after an end-to-end suture used as a gold standard treatment. In addition, PSELT was used in presence or absence of transplanted, nestin-positive boundary cap-derived stem cells (BCSC) to assess the effect of the peptide in combination with a cell therapy. The analyses revealed that PSELT-treated animals exhibit a better motor recovery in terms of protraction amplitude and velocity of vibrissae compared to control and end-sutured animals. Moreover, administration of PSELT following injury enhanced muscle innervation, axonal elongation and myelination of newly formed nerve fibers. PSELT displayed a better therapeutic effect than xenotransplantation of BCSC. When PSELT was used in the presence of BCSC, no additional beneficial effect was observed in comparison to PSELT treatment alone. Accordingly, the present invention relates to use of PSELT for the treatment of nerve injuries. |
| priorityDate | 2020-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 95.