http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022038224-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_616c0b9f201a246447feb37628e23d47 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-518 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C327-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-38 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C327-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-51 |
| filingDate | 2021-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c89bf02eecaec4248b4286a39c34c9bb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_938feb92eba2077d7b64059306485e03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47df6de035694c8c1fa207201f61740d |
| publicationDate | 2022-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2022038224-A1 |
| titleOfInvention | Method for the preparation of aryl or heteroaryl substituted carbonyl or nitrile compounds |
| abstract | A method for the preparation of an alpha-substituted carbonyl compound or an alpha- substituted nitrile compound carrying an aryl or heteroaryl group as an alpha-substituent, said method comprising reacting a sulfoxide compound S1 comprising a substituted aryl or heteroaryl group, wherein a sulfinyl moiety is attached to a carbon ring atom of an aromatic ring, with a reactant selected from the following reactants A1, A2 and A3: an alkyne compound A1, which is selected from an ynamide, an ynolether, a thioalkyne and an arylalkyne, in the presence of an acid selected from a Bronsted- and a Lewis acid; a carbonyl compound A2, which is selected from a tertiary carboxylic acid amide which carries at least one hydrogen atom attached to a carbon atom in alpha-position to its carbonyl group and an aryl ketone which carries at least one hydrogen atom attached to a carbon atom in alpha-position to its carbonyl group, in the presence of an electrophilic activator; and a nucleophile A3, which is selected from a silyl enolether, an a-silyl nitrile, an a-stannyl nitrile, and a β-ketoester derivative, in the presence of an electrophilic activator; to yield an alpha-substituted carbonyl compound or nitrile compound wherein a carbon atom in alpha-position to the carbonyl group or the nitrile group, respectively, forms a bond with the carbon ring atom of the aromatic ring to which the sulfinyl moiety had been attached in the sulfoxide compound S1. |
| priorityDate | 2020-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 152.