| abstract |
The present invention covers pyrido[1,2,4]triazolo[1,5-c]pyrimidin-5- amine compounds of general formula (I): in which R1, R2, R3, R4, A1, A2, A3 and A4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant aryl hydrocarbon receptor (AHR) signaling as a sole agent or in combination with other active ingredients. |