http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022028007-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c6152fe6194bd8ab9a732b7615fc003c |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 |
| filingDate | 2021-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3413c8254ef89d8cd8e3faaaba7d638a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e0f3818a585c7684ac437ad02bf9e8d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fda44fd3839869d1ad50def0df20c35d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85eecaf4fc449b7e53de4edd564d6272 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7a4bee0a67c617fdb0162b91f4ac027 |
| publicationDate | 2022-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2022028007-A1 |
| titleOfInvention | Intermediate for preparing edoxaban free base, preparation method therefor, and application thereof |
| abstract | The present disclosure relates to an intermediate for preparing edoxaban free base, a preparation method therefor and an application thereof. The preparation method for the intermediate comprises the following steps: in an organic solvent and under an action of an alkali, subjecting 5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxylic acid or salts thereof and acyl chloride to a reaction. The intermediate can be used to synthesize edoxaban free base in a low-cost, green, environmentally friendly, simple, efficient and safe way, and the drug safety of the edoxaban product obtained can be enhanced. The preparation of edoxaban free base comprises the following steps: in an organic solvent, subjecting the salts of compound (II) and compound (IV) to a reaction; or, in an organic solvent and under an action of an alkali, subjecting the salts of compound (II) and compound (IV) to a reaction. The compound (II), the edoxaban free base and the compound (IV) have the following structures. |
| priorityDate | 2020-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.