| abstract |
The present invention relates to a drug delivery system at least comprising a drug encapsulated in a polymeric nano vesicle (polymersome), wherein the drug component is an anthracycline derivative according to the formula I wherein R1 is selected from the group consisting of H, F, -OMe or -OEt; R2 is selected from the group consisting of H, -OMe, methyl or ethyl; R3 is selected from the group consisting of H, methyl or ethyl, and R4 is H or a protecting group; the polymersome is formed by polymers comprising PEG, PEA, PCL, PTMC or PTMB building blocks or combinations thereof, wherein the polymersome polymers are, at least in part, functionalized by chemically attaching via a linker group L a targeting moiety, wherein the targeting moiety is selected from the group consisting of antibodies, peptides, aptamers or mixtures thereof. In addition, the present invention relates to process for the production of an anthracycline derivative loaded, targeted polymersome drug delivery system, a pharmaceutical composition comprising said drug delivery system and the use of said pharmaceutical composition for the treatment of cancer. |