| abstract |
A topical formulation for use in the treatment of a dermatological condition comprising: a JAK inhibitor in an oil-in-water emulsion; white petrolatum in an amount of 10% by wt; less than 0.7 ppm butyl hydroxytoluene (BHT) by wt.; oleyl alcohol in an amount of 2% by wt.; and an antimicrobial agent. A topical formulation for use in the treatment of a dermatological condition comprising: a JAK inhibitor as an oil in purified water emulsion; white petrolatum in an amount of 10% by wt.; tocopherol in an amount of less than 6.5 ppm; oleyl alcohol in an amount of 2% by wt.; polyethylene glycol 400 in an amount of 10% by wt.; diethylene glycol monoethyl ether in an amount of 15% by wt.; mineral oil in an amount of 5% by wt.; an emulsifying wax in an amount of 10% by wt.; and an antimicrobial agent comprises 2-phenoxyethanol in an amount of 1 % by wt.; wherein the topical formulation is free of BHT and thereby maintains a yellowness index of less than 6 when stored at 40 degrees C for 16 weeks and not more than 10 when stored for 24 weeks at 40 degrees C. Said composition for use in treating or preventing a disease or condition selected from psoriasis, atopic dermatitis, atopic eczema, chronic hand eczema, uticaria, vitiligo, cutaneous lupus and alopecia areata. |