http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022007752-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27fade90728c3023697f458de968333c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D253-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-53 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D253-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-53 |
| filingDate | 2021-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f41a71ddf2edc0a0e48f0dfe65c05c96 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a25246ff0e582858382e8c055e2dfaaa |
| publicationDate | 2022-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2022007752-A1 |
| titleOfInvention | New crystal form of benzamide compound and dihydrochloride thereof, and preparation method therefor |
| abstract | The present invention relates to the field of chemical medicines, and particularly to a new crystal form of a free base and dihydrochloride of benzamide compounds, and a preparation method therefor. Provided in the present invention are a method for preparing dihydrochloride crystal form J, dihydrochloride crystal form M, dihydrochloride crystal form E, dihydrochloride crystal form F, dihydrochloride crystal form H, dihydrochloride crystal form N, dihydrochloride crystal form Q, dihydrochloride crystal form S, dihydrochloride crystal form T, dihydrochloride crystal form K and free base crystal form A, free base crystal form B and free base crystal form C of a compound of formula (I), and the use thereof. Dihydrochloride crystal form J, dihydrochloride crystal form M, dihydrochloride crystal form E, dihydrochloride crystal form F, dihydrochloride crystal form H, dihydrochloride crystal form N, dihydrochloride crystal form Q, dihydrochloride crystal form S, dihydrochloride crystal form T, dihydrochloride crystal form K and free base crystal form A, free base crystal form B and free base crystal form C of the compound of formula (I) provided in the present invention have advantages in terms of at least one of the following aspects: solubility, melting point, stability, dissolution rate, hygroscopicity, adhesion, fluidity, bioavailability, processing performance, purification effect, preparation production, safety etc., which provides a new better choice for the preparation of a pharmaceutical preparation containing a free base of the compound of formula (I) and the dihydrochloride thereof, and is of great significance to drug development. |
| priorityDate | 2020-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.