| abstract |
The invention is related to new 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine (2a-j) and 7 new 1,2,4-triazole (3a-g) derivatives and synthesis of these compounds, in vitro anticancer activity studies and molecular docking and in silico ADME studies. It was determined that compounds 2c, 2d, 3b, 3d and 3g of the invention exert their cytotoxic and apoptotic effects on A549 human lung adenocarcinoma cell line through Akt inhibition. |