| abstract |
The present invention relates to a preparation method for a CDK4/6 inhibitor, and specifically relates to a preparation method for a compound of formula (I): 5-fluoro-4-(3-isopropyl-2-methyl-2H-indazol-5-yl)-N-(5-(piperazin-1-yl)pyrazol-2-yl)pyrimidine-2-amine. The provided preparation method has cheap and readily available starting materials and reagents, greatly simplified total reaction steps, shortened reaction time, improved total yield and a high purity of the key intermediate and final product, being suitable for industrial production. |