http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021252803-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69ece09bafee7e0c49d1f7951a3faa2c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6929 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6917 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 |
| filingDate | 2021-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45072d8391198a285327ce10e104c5e7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8565d4977a5f668f6f136aa4a69e6c5a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a200ccb6e2e03456728c5aa423106c01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85be13102950c3455f365a306bf7cce4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b8f348f26c456fe25955cd5027e290b |
| publicationDate | 2021-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2021252803-A1 |
| titleOfInvention | Nanolipoprotein-polypeptide conjugates and compositions, systems, and methods using same |
| abstract | The present invention generally relates to nanolipoprotein particle conjugates comprising at least one polypeptide and nanolipoprotein particle conjugates comprising at least one short peptide between 20-60 amino acids in length. Also provided are related compositions and systems, and methods of preparing and using same. In particular, nanolipoprotein particle (NLP) conjugates with antigen-binding fragments (Fabs) are provided, where the NLP comprises a bilayer of membrane-forming lipids encircled by scaffold proteins, and the Fabs are conjugated to one or both bilayer surfaces. In some embodiments, the (NLP) conjugates further comprise a short peptide 20-60 amino acids in length. The conjugates, and related compositions and systems, generally show good stability and manufacturability, retain antigen¬ binding activity, and can enhance antigen-binding potency, providing versatile platforms for delivery of Fab and Fab-based therapeutics and diagnostics, as well as providing stable platforms for delivering other therapeutic and/or diagnostic agents. |
| priorityDate | 2020-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 274.