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filingDate 2021-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2021-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2021239838-A2
titleOfInvention Severe acute respiratory syndrome coronavirus 2 (sars-cov-2) polypeptides and uses thereof for vaccine purposes
abstract The Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) pandemic has undeniably emerged as the largest global health threat to humanity in this century. SARS-CoV-2 vaccines will be essential to reduce morbidity and mortality if the virus establishes itself in the population. The inventors have set up candidate vaccines against SARS-CoV-2. In particular, the inventors have identified specific epitopes to be included in vaccine candidates thanks to in silico analysis of the amino-acid sequence of these proteins to map predicted MHC-I and -II epitopes by online software (NetMHC-4.0 and NetMHCII-2.3) and peptide binding prediction software. B cell epitopes were also mapped using online software (BepiPred-2.0 and Discotope), as well as regions rich in epitopes whose sequences are homologous between SARS-CoV-2 and -CoV-1. Finally, the inventors have generated some specific CD40 antibodies comprising one or more SARS-CoV-2 polypeptide(s) of the present invention and that are suitable for vaccine purposes. Therefore, the present invention relates to SARS-CoV-2 polypeptides and uses thereof for vaccine purposes.
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