| abstract |
A micromolecular oxathiazine derivative, which belongs to the field of organic synthesis medicines and has the general formula as shown below: the micromolecular oxathiazine derivative can be used as a positive allosteric modulator of an AMPA receptor, which proves that the compound can positively regulate the AMPA receptor, so that the conformation after an agonist (such as endogenous neurotransmitter glutamic acid) is combined with the receptor is more stable, thereby reducing the deactivation rate of the receptor, inhibiting the desensitization of the receptor, and enhancing the function of the AMPA receptor. |