http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021238312-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bb2651d5e254745841d10fd3e5467a90 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J31-006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-002 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 |
| filingDate | 2021-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4679b22cbfa44183e893a4225ef9b6c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f5a1c3229161dd675539b2ff3620e8c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2086068128526b5bbe7f74ff3bfa9410 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98547ca02db8aa097aabf8da2fce2cb7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c6140a357443877081bdde8cc16f0e9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d8cf45000adc7abad2709e2fee4fda4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d136500fa86ba7ec64cb8b5da323b34 |
| publicationDate | 2021-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2021238312-A1 |
| titleOfInvention | Method for purifying progesterone |
| abstract | Disclosed is a method for purifying progesterone, belonging to the technical field of preparation and processing of steroid hormone medicaments. In the method, aldehyde impurities in crude progesterone are used to react with a sulfur-containing nucleophile reagent to generate highly polar hydroxysulfonates to achieve solubility difference with progesterone, then add water for precipitation, perform filtration, and the filter cake is washed with water and dried, so as to obtain highly pure progesterone having a content higher than 99.5% and the total content of impurity aldehydes lower than 0.2%. The purification method of the present invention avoids the technical bottleneck of progesterone purification in the prior art. Raw materials of reagents used in the reaction process are cheap and easily available. The purification process is simple and convenient to operate, has low requirements on equipment, and has low costs. The purification process is mild and safe, the conditions are easy to control, and the product purification recovery rate is high. The reagents used have low environmental pollution, and particularly, chromium-containing high-pollutive reagents are not used. The purification method satisfy the industry development trend of green chemistry, and have good economic and social benefits. |
| priorityDate | 2020-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.