| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f47c750954e13a1ed0be96c1bf1c51c7 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y115-01001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y305-04004
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y305-04005 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y115-01001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y305-04004
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y305-04005 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-86 |
| filingDate |
2021-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e4ebf2d7e1ba8b735fcc1f9c0b91c84
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_009d9b0ef0d48667c2529cd9776082a4 |
| publicationDate |
2021-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2021231603-A2 |
| titleOfInvention |
Compositions and methods for base specific mitochondrial gene editing |
| abstract |
Provided herein are compositions that include proteins that include a mitochondrial localization amino acid sequence attached to a base editor fusion protein including a nucleotide base-modifying enzyme and an RNA-guided DNA endonuclease enzyme with modified endonuclease activity. Provided herein are nucleic acids encoding the proteins and vectors including the nucleic acids. Provided herein are pharmaceutical compositions including the compositions, proteins, nucleic acid and vectors. Provided herein are related methods for modifying mitochondrial DNA and treating mitochondrial disorders. |
| priorityDate |
2020-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |