http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021228776-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_17832f1285ef628523e702754592582a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ec0024795f45a646ef64b3664ab8a26d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-582 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09B67-0083 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5076 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09B67-0092 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-533 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09B67-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09B1-00 |
| filingDate | 2021-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72b4f79268a863d4d0fa30bd84d0f530 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a10ec9b3fc28e5038ce94032298ef47e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6da938aa86eaf2f68025b2ed2b72de71 |
| publicationDate | 2021-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2021228776-A1 |
| titleOfInvention | Bioinspired fluorescent probes for reversible staining of the endoplasmic reticulum and for further analytical applications |
| abstract | The present invention relates to the field of fluorescent compounds and dyes. In particular, it provides the use of a polyphenol, such as quercetin or luteolin, and a diaryl borinic compound, e.g., 2-aminoethoxydiphenyl borate (also referred to as 2-APB, diphenylborinic acid 2-aminoethyl ester, DPBA or Neu's reagent), in combination with an agent capable of providing an aprotic environment selected from the group consisting of the endoplasmic reticulum (ER) of an animal cell, a protein, a polypeptide, and a solid preferably, crystalline phase of a complex formed by the polyphenol and the diaryl borinic compound, for generating an increased fluorescence. The invention teaches the use of a polyphenol and a diaryl borinic compound for selective fluorescent staining of the endoplasmic reticulum (ER) of an animal cell and a corresponding method as well as kits useful to this end. Advantageously, the ER can be reversibly stained, and, depending on the selection of the polyphenol, different wavelengths of fluorescence can be obtained. Also provided is the use of a polyphenol, a diaryl borinic compound, and an agent capable of providing an aprotic environment, e.g., a protein, for determining the proton-donating ability of a solvent, or determining the presence and/or concentration of the agent, the polyphenol or the diaryl borinic compound. Complexes of the invention, e.g., in solid or crystalline form, may also be used as fluorescent dyes or paints, or for providing light, e.g., in a display. |
| priorityDate | 2020-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 116.