| abstract |
A polycyclic amide derivative as a CDK9 inhibitor, and a preparation method therefor and use thereof. The polycyclic amide derivative exhibits an excellent CDK9 enzyme inhibitory activity, and can be used for preparing a medicine for treating cancers, wherein the cancers are especially hematological cancers, including acute myeloid leukemia, multiple myeloma, chronic lymphocytic leukemia, follicular lymphoma and solid tumors including breast cancer, prostate cancer, ovarian cancer, hepatocellular cancer, pancreatic cancer, renal cancer, gastric cancer, colorectal cancer and lung cancer. |