http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021226814-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_91badada62eb16e67d6e19bdf5f9fef6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_166b29e6819ad4a764affeb91feaeded |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16 |
| filingDate | 2020-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30b180617fc2518473e05930902dfe5d |
| publicationDate | 2021-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2021226814-A1 |
| titleOfInvention | Small-molecule compound spam1 for up-regulating neuropeptide pacap and receptor pac1-r thereof, and preparation method therefor and application thereof |
| abstract | Disclosed are a small-molecule compound SPAM1 for up-regulating a neuropeptide PACAP and a receptor PAC1-R thereof, and a preparation method therefor and an application thereof. The structure of the SPAM1 is as shown in formula (I), wherein R=none or H 2O or HCl; the SPAM1 is small in molecular weight, and can efficiently pass through biological barriers comprising a blood brain barrier, a blood testis barrier, and the like; the SPAM1 up-regulates, by positive feedback, expression of a neurotransmitter/neuromodulator PACAP secreted by the hypothalamus-pituitary gland and a specific receptor PAC1-R of the PACAP and acts on downstream glands of the gonadal axis and the adrenal axis, and thus, the regulation and control effects for the PACAP are comprehensive; the SPAM1 specifically targets PAC1-R1, only acts on cells and tissues naturally expressing PAC1-R in an nervous system and an endocrine system, and has relatively small side effects. Therefore, the SPAM1 will become a novel small-molecule compound drug for effectively treating and preventing functional aging and disorder, closely related to the neuropeptide PACAP, of the nervous system, the endocrine system, and the immune system. |
| priorityDate | 2020-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.