| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a819eda0adf22936a52362eeebb9fb4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e40ceab05afbe887909abf7467edd987 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2037-0046
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2037-0061
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M5-3298 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M37-0015
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-688
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-4839
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0021
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-685 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M5-158
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M5-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B17-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B5-00 |
| filingDate |
2021-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a79f673e765a00202a2e6aa4e556aa23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1ea3df11a4ff5082a2c675f8ab419ab |
| publicationDate |
2021-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2021225826-A1 |
| titleOfInvention |
Bioorthogonal catalytic patch and methods of using the same |
| abstract |
A bioorthogonal catalytic patch integrates TiO2 nanosheets populated with metallic nanoparticles into polyvinyl alcohol-based microneedles arranged in an array. This bioorthogonal patch-based device is robust, removable and can effectively mediate the conversion of caged substrates into their active states once placed at the site of application. The capacity of the patch in executing bioorthogonal catalysis in high-level living systems was demonstrated by localized dealkylation of a caged doxorubicin prodrug at the melanoma tumor site and restoration of its pharmacological properties for cancer therapy. This in situ applied patch facilitated to enhance the local treatment efficacy and eliminate off-targeted prodrug activation or dose-dependent side effect towards healthy organs or tissues located away from the application site. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114939162-A |
| priorityDate |
2020-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |