| abstract |
Disclosed are a substituted pyrrolidine compound and the use thereof in medicine. In particular, disclosed are a substituted pyrrolidine compound or a stereoisomer, a tautomer, a nitrogen oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt thereof or a prodrug thereof, and a pharmaceutical composition containing the above-mentioned compound. Also disclosed is the use of the above-mentioned compound or the pharmaceutical composition thereof in the preparation of a drug, the drug being used to treat PDE4-related diseases, such as atopic dermatitis (AD) or chronic obstructive pulmonary disease (COPD). |