http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021212243-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f5b831dcc6aac046995e396d8ceab6bf |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-43509 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-435 |
| filingDate | 2020-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a148e4dad78c37a15ce9866bd4bd05aa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_269df6b877f62111b7407fb161ef2813 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a9d66eaed386b8f0819cba9d4958a8f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9bc378bf3ef7bfb11a8f008fd0a6856 |
| publicationDate | 2021-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2021212243-A1 |
| titleOfInvention | Avermectin-sensitive and avermectin-insensitive sea lice glucl receptors and uses thereof as therapeutic targets for detecting antiparasitic drugs against caligus rogercresseyi |
| abstract | The present invention relates to the identification of new glutamate-activated chloride channels of Caligus rogercresseyi (CrGluCl), corresponding to CrGluCl-B to CrGluCl-E receptors, according to SEQ ID N°: 2-5, and the use of these channels as therapeutic targets for detecting antiparasitic drugs against Caligus rogercresseyi. The procedure for testing such drugs corresponds to a high-throughput method that comprises: introducing individually into an expression vector, any of SEQ ID N°: 2-5, to express a single CrGluCl channel selected from the CrGluCl-B, CrGluCl-C, CrGluCl-D or CrGluCl-E receptors; or, co-expressing in different vectors, two or more channels in any combination, either of new channels (CrGluCl-B to CrGluCl-E) or together with known channels (CrGluCl-A). Said vectors are introduced into a host cell, which is exposed to a potential-sensing fluorescent dye that allows each test compound to be classified as active or inactive based on the ability of the test compound to cause a change in the fluorescence. |
| priorityDate | 2020-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.