| abstract |
Described are processes for the manufacture of compounds containing a (S)-4,5-dihydro-lH-pyrazole ring. These processes include a chiral resolution step of an intermediate using selected chiral resolving agents. For example, the chiral resolving agents may be selected from (-)- quinine, (R)-phenethylamine, (S)-phenethylamine, (S)- 1 -naphthylethy lamine, (R)-(-)-2-amino-3-methyl-l-butanol, (-)-cinchonidine, (-)- spartein, (R)-l -naphthylethy lamine, D- arginine, L-lysine, (S)-(+)-2-pyrrolidinemethanol and(lR,2S)-(+)-cis-l-amino-2-indanol. |