| abstract |
Described herein are binding proteins useful against ACE2-targeted viruses (e.g., SARS-CoV and SARS-CoV-2, etc.), and methods of using them. These binding proteins may include an extracellular portion of angiotensin-converting enzyme 2 (ACE2), excluding the collectrin domain, and a flexible polypeptide flexible linker coupling the ACE2 portion to a fragment crystallization (Fc) domain. These binding proteins dimerize, and the flexible linker may be chosen to be sufficiently long to permit concurrent interaction with multiple Spike (S) proteins on the ACE2-targeted virus. |