| abstract |
The present invention provides tools and methods for the TCR independent activation of T-cells, in particular TCR negative T-cells. In particular, the invention relates to CD3- fusion protein comprising a CDS heterodimer comprising a transmembrane domain, and a CD3ΞΆ domain. The invention further relates to a nucleic acid molecule encoding such a CD3-fusion protein, a T cell encoding such a CD3-fusion protein as well as said T cell for medical use. Further, the use of the T cell for testing and characterization of exogenous effector molecules is described. |