http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021188012-A1

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filingDate 2021-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75bc8da78ce7160dd9719ef280b5768d
publicationDate 2021-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2021188012-A1
titleOfInvention DRUG IN THE FORM OF A COMPLEX OF 3,3'-DIINDOLYLMETHANE WITH β-CYCLODEXTRIN
abstract What is claimed is a drug based on 3,3'-diindolylmethane and β-cyclodextrin, wherein the ingredient ratio is as follows: 3,3'-diindolylmethane 10-20 wt %, β-cyclodextrin 80-90 wt %. The method for producing said drug consists in dissolving β-cyclodextrin in water to give a solution concentration of 10-25% based on dry β-cyclodextrin. 3,3'-diindolylmethane is added to the solution produced at the above-mentioned weight ratio. The solution is stirred, the resulting suspension is spray-dried using a gas at a temperature of 180°C, and the resulting dry product is sieved through a mesh to give a powder. A method for treating human papillomavirus (HPV)-associated cervical neoplasia consists in a single administration of a human papillomavirus vaccine to a female patient. The female patient is then subjected to a topical treatment using the drug comprising 3,3'-diindolylmethane complexed with β-cyclodextrin. The invention makes it possible to increase the solubility of the drug in water and the stability thereof, and to eliminate a burning sensation and discomfort during treatment.
priorityDate 2020-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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