| abstract |
A tri-aromatic ring compound containing a urea structure having the structure shown in formula (I) or a pharmaceutically acceptable salt or stereoisomer or prodrug molecule or metabolite or solvate thereof. The compound can effectively inhibit kinase, especially FLT3 and RET kinase so as to regulate activation of a plurality of downstream pathways. The compound can be used for preparing medicines for preventing and treating various diseases related to RET kinase, FLT3 kinase and/or Kit kinase, such as leukemia and tumors. |