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filingDate 2021-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82cf75cee0eec2667773fafbad44dc41
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publicationDate 2021-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2021163059-A1
titleOfInvention Maging and sequencing protein-dna interactions in single cells using integrated microfluidics
abstract The present disclosure provides materials and methods for co-determining the cellular location and nucleotide sequence of a DNA that is contacted by (or in close proximity to) a protein of interest in a single cell. Thus the present disclosure provides methods and materials wherein the cellular location of the DNA comprising a DNA-binding site or otherwise in close proximity to a protein of interest is coupled to the sequence of said DNA to provide contemporaneous imaging and sequence measurement of a protein-DNA interaction.
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