| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f4e329d91d0dc4575d1a5b3dd859d5c3 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-485
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-177 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 |
| filingDate |
2020-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9be879a59c536a5d7a785e57485a3a03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1ce44999bbb75ec21905cff56dbb8f6 |
| publicationDate |
2021-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2021158317-A1 |
| titleOfInvention |
Methods for preventing and reversing opioid analgesic tolerance in subjects with chronic pain |
| abstract |
The current disclosure provides methods for treating chronic pain. The present methods reduce opioid analgesic/antiallodynic tolerance in a subject with chronic pain and prevent the development of opioid analgesic/antiallodynic tolerance. More specifically, the inventive methods include the administration of a caveolin-1 scaffolding domain competing polypeptide (CSD) and/or a non-receptor tyrosine kinase (c-Src) inhibitor to reduce opioid analgesic/antiallodynic tolerance as well as prevent the onset of opioid analgesic/antiallodynic tolerance in a subject with chronic pain. |
| priorityDate |
2020-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |