| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7962628e578d4748773a55cbaf3305e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d9bbc5ff0cb9ef4792989dceeeb7f49b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2d99c268de6baf70ec1359f51c7eab06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6404251d4bb60b6675a5f872b79efaa0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_60b07882f5423cf652333c035f90c234 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B15-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16C20-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-582
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-245
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-315 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B99-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B15-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16C99-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-315
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-245
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-24 |
| filingDate |
2021-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3de941bb337cea38563d04b3c0ec00e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3f48c51d0ceaf7adbfd1e1124878bad
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d4736cbaa8a780ac18092ceaf513e8e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45c0e0bc1485d98bddb2fc7399338c76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_639707fb73a3d3b41158d72448b003db |
| publicationDate |
2021-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2021155459-A1 |
| titleOfInvention |
Improved processes for rationally-designing and producing biomolecules |
| abstract |
Improved processes for rationally-designing and producing biomolecules are disclosed herein. More specifically, disclosed processes comprise the steps of (i) selecting at least one biomolecule suitable for modification; (ii) obtaining at least one structure of the at least one biomolecule; (iii) simulating the molecular dynamics of the at least one structure to generate dynamic information about at least one position within the at least one structure; (iv) using the dynamic information to calculate a score for the at least one position; (v) comparing the score with at least one reference score to identify at least one target position within the biomolecule suitable for modification; and (vi) modifying the at least one target position. As proof-of-concept, the disclosed processes were used to rationally-design and produce maltooligosaccharide-detecting biosensors based on Streptococcus pneumoniae MalX, homogalacturonan breakdown product-detecting biosensors based on Yersinia enterocolitica TogB, and biosensors for observing conformational changes based on Escherichia coli EF-Tu. |
| priorityDate |
2020-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |