| abstract |
Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized PNPLA3 locus and methods of making and using such non-human animal genomes, non-human animal cells, and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized PNPLA3 locus express a human PNPLA3 protein or a chimeric PNPLA3 protein, fragments of which are from human PNPLA3 . Methods are provided for using such non-human animals comprising a humanized PNPLA3 locus to assess in vivo efficacy of human - PNPL A3 -targeting reagents such as nuclease agents designed to target human PNPLA3. |