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filingDate 2021-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2021-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2021154682-A1
titleOfInvention Tissue dosing for intraluminal local drug delivery
abstract Devices, systems and methods for localized delivery of a chemotherapy, hormonal therapy or targeted drug/biologic therapy to a target tissue area of an internal body organ of a patient. A catheter forms a sealed treatment chamber in a natural lumen extending through the target tissue area. Air is purged from the chamber, which is then filled with a liquid drug solution for an adequate treatment session time, solution volume and drug concentration to saturate the target tissue area, thereby providing the treatment. The drug concentration in the liquid soaking solution may be formulated to approximate the known maximum plasma concentration achieved during systemic delivery of the same drug. An integrated pressure relief circuit may be included to avoid unsafe pressure levels in the isolated chamber. The chamber is evacuated at the end of the treatment session.
priorityDate 2020-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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